Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus
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چکیده
منابع مشابه
Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus.
Brain-derived neurotrophic factor (BDNF) and its signal transducing receptor, the TrkB tyrosine protein kinase, are expressed at high levels in the hippocampus of the adult brain, suggesting a role for BDNF mechanisms in neuronal plasticity. To test this hypothesis, we used defined lesions of perforant path and fimbria-fornix, two major hippocampal afferents, to remove synapses on dendrites of ...
متن کاملCritical role of trkB receptors in 1 reactive axonal sprouting and hyperexcitability after axonal injury
25 Traumatic brain injury (TBI) causes many long-term neurological complications. Some of these 26 conditions, such as posttraumatic epilepsy, are characterized by increased excitability that 27 typically arises after a latent period lasting from months to years, suggesting that slow injury28 induced processes are critical. We tested the hypothesis that trkB activation promotes delayed 29 injur...
متن کاملCritical role of trkB receptors in reactive axonal sprouting and hyperexcitability after axonal injury.
Traumatic brain injury (TBI) causes many long-term neurological complications. Some of these conditions, such as posttraumatic epilepsy, are characterized by increased excitability that typically arises after a latent period lasting from months to years, suggesting that slow injury-induced processes are critical. We tested the hypothesis that trkB activation promotes delayed injury-induced hype...
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In this paper we have investigated the hypothesis that neural activity causes rapid activation of TrkB neurotrophin receptors in the adult mammalian CNS. These studies demonstrate that kainic acid-induced seizures led to a rapid and transient activation of TrkB receptors in the cortex. Subcellular fractionation demonstrated that these activated Trk receptors were preferentially enriched in the ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1993
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.13-09-04001.1993